KMID : 1038120230560040470
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Clinical Endoscopy 2023 Volume.56 No. 4 p.470 ~ p.478
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The pattern of metachronous recurrence after endoscopic submucosal dissection for gastric adenocarcinoma and dysplasias
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Suk Sun-Ah
Seo Yeon-Joo Cheung Dae-Young Lee Han-Hee Kim Jin-Il Park Soo-Heon
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Abstract
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Background/Aims : Metachronous recurrence incidences and risk factors following endoscopic submucosal dissection (ESD) for gastric adenocarcinoma and dysplasias were investigated.
Methods : Retrospective review of electronic medical records of patients who underwent gastric ESD at The Catholic University of Korea, Yeouido St. Mary¡¯s Hospital.
Results : A total of 190 subjects were enrolled for analysis during the study period. The mean age was 64.4 years-old and the male sex occupied 73.7%. The mean observation period following ESD was 3.45 years. The annual incidence rate of metachronous gastric neoplasms (MGN) was about 3.96%. The annual incidence rate was 5.36% for the low-grade dysplasia group, 6.47% for the high-grade dysplasia group, and 2.74% for the EGC group. MGN was more frequent in the dysplasia group than in the EGC group (p<0.05). For those with MGN development, the mean time interval from ESD to MGN was 4.1 (¡¾1.8) years. By using the Kaplan?Meier model, the estimated mean MGN free survival time was 9.97 years (95% confidence interval, 8.53?11.40) The histological types of MGN were not related to the primary histology types.
Conclusions : MGN following ESD developed in 3.96% annually and MGN was more frequent in the dysplasia group. The histological types of MGN did not correlate with those of primary neoplasm.
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KEYWORD
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Early gastric cancer, Endoscopic mucosal resection, Endoscopic submucosal dissection, Gastric dysplasia, Metachronous gastric neoplasm
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